A COMPARISON OF SETUP ERRORS AND SAFETY MARGINS BETWEEN 3-POINT AND 5-POINT IMMOBILIZATION SYSTEMS IN HEAD AND NECK RADIATION THERAPY AT MILITARY HOSPITAL 175

Authors

  • Ngọc Nguyễn Thế Bệnh viện Quân y 175
  • Khánh Bùi Quốc Bệnh viện Quân y 175
  • Bằng Lý Công Bệnh viện Quân y 175
  • Hằng Đỗ Hải Bệnh viện Quân y 175
  • Công Nguyễn Thành Bệnh viện Quân y 175
  • Hiển Nguyễn Thị Bệnh viện Quân y 175
  • Thắng Nguyễn Quyết Bệnh viện Quân y 175
  • Hà Nguyễn Văn Bệnh viện Quân y 175

DOI:

https://doi.org/10.59354/ydth175.2026.500

Keywords:

Head and neck cancer, IMRT, setup error, safety margin, 5-point immobilization, Van Herk

Abstract

Objective: To compare setup errors and calculate safety margins (PTV margins) between 3-point and 5-point HeadSTEP immobilization systems in Intensity-Modulated Radiation Therapy (IMRT) for head and neck cancer at Military Hospital 175.

Methods: A total of 2539 iViewGT verification image sets from 101 treatment plans (51 with 3-point and 50 with 5-point masks) were analyzed. Systematic errors (∑), random errors (σ), and safety margins (A) were determined in three directions: Anterior-Posterior (A.P), Left-Right (L.R), and Superior-Inferior (S.I) using the Van Herk formula (A=2.5 ∑ₚₒₚ + 0.7 σₚₒₚ, A=2.5 ∑ₚₒₚ + 0.7 σₚₒₚ).

Results: The 5-point system demonstrated superior setup accuracy. Specifically, the safety margin (A) in the A.P direction was reduced from 4.3 mm to 2.8 mm, and the S.I direction from 4.1 mm to 3.45 mm. The L.R direction remained stable below 3 mm. Systematic error (∑) showed the most significant improvement in the A.P direction, decreasing from 1.15 mm to 0.74 mm.

Conclusions: Utilizing a 5-point immobilization system significantly enhances patient setup precision, allowing for a PTV margin reduction to below 3.5 mm. This optimization facilitates better healthy tissue sparing and treatment efficacy.

References

1. Bray, F., et al. (2024). “Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries” CA: A Cancer Journal for Clinicians, 74(3), 229-263. DOI: 10.3322/caac.21834.

2. Van Herk, M. (2004). “Errors and margins in radiotherapy” Seminars in Radiation Oncology, 14(1), 52-64. DOI: 10.1053/j.semradonc.2003.10.003.

3. Gilbeau, L., et al. (2001). “Comparison of setup accuracy of three different thermoplastic masks for the treatment of brain and head and neck tumors” Radiotherapy and Oncology, 58(2), 155-162. DOI: 10.1016/S0167-8140(00)00300-8.

4. Li, Q., et al. (2021). “Clinical evaluation of setup errors and PTV margins using different immobilization systems in head and neck cancer radiotherapy” Radiation Oncology, 16(1), 1-9.

5. Chen, A. M., et al. (2011). “Evaluation of the planning target volume in the treatment of head and neck cancer with IMRT: What is the appropriate expansion margin in the setting of daily image guidance?” International Journal of Radiation Oncology Biology Physics, 81(4), 943-949. DOI: 10.1016/j.ijrobp.2010.07.1989.

6. Navran, A., et al. (2019). “The impact of margin reduction on outcome and toxicity in head and neck cancer patients treated with image-guided volumetric modulated arc therapy (VMAT)” Radiotherapy and Oncology, 130, 25-31. DOI: 10.1016/j.radonc.2018.09.006.

Published

30-06-2026

How to Cite

Nguyễn Thế , N., Bùi Quốc , K., Lý Công , B., Đỗ Hải , H., Nguyễn Thành , C., Nguyễn Thị , H., … Nguyễn Văn , H. (2026). A COMPARISON OF SETUP ERRORS AND SAFETY MARGINS BETWEEN 3-POINT AND 5-POINT IMMOBILIZATION SYSTEMS IN HEAD AND NECK RADIATION THERAPY AT MILITARY HOSPITAL 175. Journal of 175 Practical Medicine and Pharmacy, (46), 9. https://doi.org/10.59354/ydth175.2026.500