THE ROLE OF BIOMARKER CD64 ON NEUTROPHILS IN THE DIAGNOSIS OF SEPSIS AT MILITARY HOSPITAL 175
DOI:
https://doi.org/10.59354/ydth175.2025.390Keywords:
CD64, neutrophils, sepsisAbstract
Objectives: Evaluation of the role of Neutrophil CD64 as a biomarker in the early detection and diagnosis of Sepsis at Military Hospital 175.
Methods: The study was designed using a cross-sectional descriptive study method.
Results: The median value of CD64 on neutrophils in the sepsis group was 6345 molecules/cell (95% CI, 3249 - 13285), which was statistically significantly higher than that in the non-sepsis group - 1483 molecules/cell (95% CI, 1064 - 2319), with p < 0.01. At a cut-off value of 3028 molecules/cell, CD64 demonstrated the ability to diagnose sepsis with a sensitivity of 83% and a specificity of 90%. CD64 showed high diagnostic value for sepsis with an area under the curve (AUC) of 0.91, p < 0.01, significantly outperforming both procalcitonin (PCT) and white blood cell (WBC).
Conclusions: CD64 on neutrophils demonstrates excellent diagnostic ability for sepsis with an area under the curve (AUC) of 0.91, p < 0.01.
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